Home BannerHome Banner

Uncontrolled gout is chronic and systemic,
and affects patients beyond the joints7,8

Patients experience a wide range of symptoms beyond
severe pain and tophi, including7:

Uncontrolled gout is chronic and systemic,
and affects patients beyond the joints7,8

Patients experience a wide range of symptoms beyond
severe pain and tophi, including7:

  • Acute and persistent inflammatory arthritis7
  • Disability associated with bone and joint destruction4
  • Potential osteoarthritis7
  • Chronic kidney disease–related mineral bone disorder3
  • Ischemic heart disease and congestive heart failure9-11

FIND OUT MORE


At Horizon, we created EvolutionofGout.com to bring impactful gout research like this to light. We believe that a deeper understanding of the science behind gout can ultimately lead to precise treatment and improved patient outcomes.

Vital organs are at risk too. Watch now

Why Does Pain Resolve When Crystals Are Still Present?

Schett pic

Professor Georg Schett, MD
Erlangen, Germany

As he sought to answer the question of why gout flares subside, Professor Georg Schett, MD, discovered a telling relationship between aggregated neutrophil extracellular traps (aggNETs), pain resolution, and the development of tophi.

GET THE DETAILS

What Are the Consequences of Inadequate Control?

Dalbeth

Professor Nicola Dalbeth, MD
Auckland, New Zealand

Reducing the incidence of flares is often the main concern for gout patients. But Professor Nicola Dalbeth, MD, committed herself to examining an often-overlooked yet serious consequence of gout: bone erosion.

REVIEW THE RESEARCH

  • Nickeleit V, et al. Nephrol Dial Transplant. 1997;12(9):1832-1838.
  • Klauser AS, et al. JAMA Cardiol. 2019;4(10):1019-1028.
  • Doghramji PP, et al. Postgrad Med. 2012;124(6):98-109.
  • Dalbeth N, et al. Lancet. 2016;388(10055):2039-2052.
  • Park JJ, et al. BMJ Open. 2014;4(7):e005308.
  • Khanna PP, et al. J Clin Med. 2020;9(10):3204.
  • Becker MA, et al. Ann Rheum Dis. 2013;72(9):1469-1474.
  • Stewart S, et al. Semin Arthritis Rheum. 2020;50(4):805-811.
  • Becker MA, et al. J Rheumatol. 2009;36(5):1041-1048.
  • Afsar B, et al. J Nephrol. 2019;32(5):709-717.
  • Khan A, et al. Pak J Med Sci. 2017;33(2):330-334.