OH, THE PLACES URATE WILL GO!

A Vodcast Series on Systemic Urate Deposition

Dr. Ada Kumar

A practicing radiologist for nearly 15 years, Dr. Kumar is the former chief resident at Brigham and Women’s Hospital, Harvard Medical School and has completed a fellowship in musculoskeletal imaging at the University of Chicago. She is excited to use her expertise in radiology investigating ways imaging can yield innovative insights into our understanding of gout and recognition of systemic deposition of urate and its potential implications.

Dr. Ada Kumar
Dr. Ada Kumar

Radiologist

THE NOT-SO-GREAT PLACES URATE CAN DEPOSIT

The evidence is growing that urate deposits are much more than just a joint problem. Urate can deposit almost anywhere in the body, including in the heart, kidney, spine, eyes and skin.1-7

In this vodcast (video podcast) series, Dr. Ada Kumar examines the surprising and concerning places where urate deposition has been found throughout the body, and what it means for patients with systemic urate deposition.

EPISODE 1:

A HEART-TO-HEART ABOUT GOUT

PART 1

Dr. Kumar takes a look at the potential dangers of urate deposition in the heart with a focus on arterial deposition.

EPISODE 1:

A HEART-TO-HEART ABOUT GOUT

PART 2

In part 2 of her investigation of urate deposition in the heart, Dr. Kumar examines deposits in the cardiac valves and myocardium.

EPISODE 2:

URATE IN THE KIDNEYS? NO KIDDING!

Dr. Kumar looks at the connection between urate deposition in the kidney and decreased renal function.

EPISODE 3:

SPINE-TINGLING IMAGES—URATE DEPOSITION IN THE BACK

Dr. Kumar explores evidence of gout and urate deposition along the spine.

EPISODE 4:

OPEN YOUR EYES! LOOKING AT URATE DEPOSITION

Dr. Kumar analyzes medical images of urate deposition in the eyes and its effect on ocular function.

EPISODE 5:

URATE GETS UNDER YOUR SKIN

Dr. Kumar shows how urate deposition can affect the skin and what it means for patients.

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TAKE A DEEPER LOOK AT GOUT

View collections of gout images from various advanced imaging techniques to see the full scope of damage that tophi can cause.

See the damage

WHAT YOU CAN DO

Learn about a treatment option for chronic gout.

Find out more

Negatively birefringent crystal image (purple) used with permission from Park JJ, et al. BMJ Open. 2014;4(7):e005308.

Myocyte inclusions in the myocardium image used with permission from Frustaci A, et al. Ann Intern Med. 2020;172(5)363-365.

Kidney autopsy image used with permission from Nickeleit V, Mihatsh MJ. Nephrol Dial Transplant. 1997;12(9):1832-1838.

Spinal DECT scan used with permission from Wang JX, et al. BMC Rheumatol. 2020;4:22.

Fundoscopic photograph used with permission from Jiang Y, et al. BMC Ophthalmol. 2018;18(1):11.

Skin image used with permission from Pattanaprichakul P, et al. Dermatol Pract Concept. 2014;4(4):33-35.

References

PAGE REFERENCES

  1. Edwards NL. Primer on the Rheumatic Diseases. 13th ed. New York, NY: Springer; 2008:241-249.
  2. Doghramji PP, et al. Postgrad Med. 2012;124:98-109.
  3. Park JJ, et al. BMJ Open. 2014;4:1-6.
  4. Nickeleit V, et al. Nephrol Dial Transplant. 1997;12:1832-1838.
  5. Lu H, et al. Medicine. 2017;96(32):e7670.
  6. Lin J, et al. Int J Opthalmol. 2013;6(3):307-311.
  7. Lo TE, et al. BMJ Case Rep. [published online July 10, 2013]. doi:10.1136/bcr-2013-009735.

EPISODE REFERENCES IN ORDER OF APPEARANCE

A HEART-TO-HEART ABOUT GOUT, PART 1

  • Kuo CF, et al. Rheumatology (Oxford). 2010;49(1):141-146.
  • Klauser AS, et al. JAMA Cardiol. 2019;4(10):1019-1028.
  • Abdellatif W, et al. Ann Rheum Dis. 2019;78(suppl 2):590-592.
  • Park JJ, et al. BMJ Open. 2014;4(7):e005308.

A HEART-TO-HEART ABOUT GOUT, PART 2

  • Klauser AS, et al. JAMA Cardiol. 2019;4(10):1019-1028.
  • LaMoreaux B, Chandrasekaran V. Ann Rheum Dis. 2019;78:1906.
  • Pund EE, et al. N Engl J Med. 1960;263:835-838.
  • Curtiss EI, et al. Circulation. 1983;67(3):699-701.
  • Rohani A, et al. J Clin Imaging Sci. 2012;2:68.
  • Frustaci A, et al. Ann Intern Med. 2019. [Epub ahead of print].

URATE IN THE KIDNEYS? NO KIDDING!

  • Nickeleit V, Mihatsch MJ. Nephrol Dial Transplant. 1997;12(9):1832-1838.
  • Brown J, Mallory GK. N Engl J Med. 1950;243(9):325-329.
  • Gonick HC, et al. Ann Intern Med. 1965;62:667-674.
  • Bardin T, et al. Ann Rheum Dis. 2018;77(suppl 2):224.
  • Kim MY, et al. J of Korean Radiol Soc. 1994;31(3):523-527.
  • Hussein A, et al. Egypt J of Radiol Nuclear Med. 2015;46(4):1205-1213.
  • Jepperson MA, et al. Clin Radiol. 2013;68(12):e707-e714.
  • Fan S, et al. BMC Nephrology. 2019;20(1):95.
  • Brown J, Mallory GK. N Engl J Med. 1950;243:325-329.
  • Bluestone R, Waisman J, Klinenberg JR. Sem Arthritis Rheu. 1977;7:97-113.
  • Gonick HC, Rubini ME, Gleason IO, Sommers SC. Ann Intern Med. 1965; 62:667-674.
  • Wang XC, et al. Exp Ther Med. 2013;6(5):1243-1246.
  • Modern FW, Meisler L. Med Clin N Amer. 1952;21:941-951.
  • Johnson RJ, et al. Semin Nephrol. 2011;31(5):394-399.
  • Liebman SE, et al. Curr Rheumatol Rep. 2007;9(3)251-257.
  • Wiederkehr MR, Moe OW, et al. Clin Rev Bone Miner Metab. 2011;9(34)207-217.

SPINE-TINGLING IMAGES—URATE DEPOSITION IN THE BACK

  • Hasegawa E, et al. Rev Bras Reumatol. 2013;53(3):296-302.
  • Yang KH, ed. Basic Finite Element Method as Applied to Injury Biomechanics. Academic Press; 2018:609-654.
  • Toprover M, et al. Curr Rheumatol Rep. 2015;17(12):70.
  • Girish G, et al. Arthritis. 2013;2013:673401.
  • Chotard E, et al. Ann Rheum Dis. 2017;76:367-368.
  • Zhang H, et al. Int J Clin Exp Med. 2017;10(3):5493-5496.
  • Dhaese S, et al. Medicine (Baltimore). 2015;94(13):e676.
  • Parikh P, et al. J Rheumatol. 2010;37(10):2190-2191.
  • Lichtenstein L, et al. Am J Pathol. 1956;32(5):871-895.
  • Lu H, et al. Medicine. 2017;96(32):e7670.
  • Zhou S, et al. BMC Musculoskelet Disord. 2019;20(1):425.
  • Wang JX, et al. BMC Rheumatol. 2020;4:22.
  • Adler S, et al. Rheumatology. 2017;56(12):2243-2245.

OPEN YOUR EYES! LOOKING AT URATE DEPOSITION

  • Ao J, et al. Clin Exp Ophthalmol. 2017;45(1):73-80.
  • Odinaeva K, et al. Archiv Euromedica. 2020;10(1):111-112.
  • Odinaeva K, et al. Archiv Euromedica. 2020;10(1):109-110.
  • Jordan DR, et al. Ophthalmol Plast Reconstr Surg. 2008;24(5):403-404.
  • Morris WR, et al. Arch Ophthalmol. 2003;121(8):1195-1197.
  • Lo WR, et al. Am J Ophthalmol. 2005;140(6):1152-1154.
  • Lin J, et al. Int J Ophthalmol. 2013;6(3):307-311.
  • Coassin M, et al. Ophthalmology. 2006;113(3):462-465.
  • Jiang Y, et al. BMC Ophthalmol. 2018;18(1):11.
  • Singh JA, et al. PLoS One. 2018;13(7):e0199562.
  • McCarty CA, et al. Am J Ophthalmol. 1999;128(4):446-465.

URATE GETS UNDER YOUR SKIN

  • Pattanaprichakul P, et al. Dermatol Pract Concept. 2014;4(4):33-35.
  • Parlindungan F, et al. Am J Case Rep. 2020;21:e919349.
  • Kim M, et al. Korean J Intern Med. 2020;35(3):736-737.
  • Gianfaldoni S, et al. Open Access Maced J Med Sci. 2017;5(4):511-514.
  • Çerman AA, et al. An Bras Dermatol. 2016;91(6):855-856.