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OH, THE PLACES URATE WILL GO!

A Vodcast Series on Systemic Urate Deposition

Dr. Ada Kumar A practicing radiologist for nearly 15 years, Dr. Kumar is the former chief resident at Brigham and Women’s Hospital, Harvard Medical School and has completed a fellowship in musculoskeletal imaging at the University of Chicago. She is excited to use her expertise in radiology investigating ways imaging can yield innovative insights into our understanding of gout and recognition of systemic deposition of urate and its potential implications.

Dr. Ada Kumar
Radiologist

THE NOT-SO-GREAT PLACES URATE CAN DEPOSIT

The evidence is growing that urate deposits are much more than just a joint problem. Urate can deposit almost anywhere in the body, including in the heart, kidney, spine, eyes and skin.^1-7

In this vodcast (video podcast) series, Dr. Ada Kumar examines the surprising and concerning places where urate deposition has been found throughout the body, and what it means for patients with systemic urate deposition.

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TAKE A DEEPER LOOK AT GOUT

View collections of gout images from various advanced imaging techniques to see the full scope of damage that tophi can cause.

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WHAT YOU CAN DO

Learn about a treatment option for chronic gout.

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Negatively birefringent crystal image (purple) used with permission from Park JJ, et al. BMJ Open. 2014;4(7):e005308.

Myocyte inclusions in the myocardium image used with permission from Frustaci A, et al. Ann Intern Med. 2020;172(5)363-365.

Kidney autopsy image used with permission from Nickeleit V, Mihatsh MJ. Nephrol Dial Transplant. 1997;12(9):1832-1838.

Spinal DECT scan used with permission from Wang JX, et al. BMC Rheumatol. 2020;4:22.

Fundoscopic photograph used with permission from Jiang Y, et al. BMC Ophthalmol. 2018;18(1):11.

Skin image used with permission from Pattanaprichakul P, et al. Dermatol Pract Concept. 2014;4(4):33-35.

REFERENCES

PAGE REFERENCES

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Nickeleit V, et al. Nephrol Dial Transplant. 1997;12:1832-1838.
Lu H, et al. Medicine. 2017;96(32):e7670.
Lin J, et al. Int J Opthalmol. 2013;6(3):307-311.
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EPISODE REFERENCES IN ORDER OF APPEARANCE

A HEART-TO-HEART ABOUT GOUT, PART 1

Kuo CF, et al. Rheumatology (Oxford). 2010;49(1):141-146.
Klauser AS, et al. JAMA Cardiol. 2019;4(10):1019-1028.
Abdellatif W, et al. Ann Rheum Dis. 2019;78(suppl 2):590-592.
Park JJ, et al. BMJ Open. 2014;4(7):e005308.

A HEART-TO-HEART ABOUT GOUT, PART 2

Klauser AS, et al. JAMA Cardiol. 2019;4(10):1019-1028.
LaMoreaux B, Chandrasekaran V. Ann Rheum Dis. 2019;78:1906.
Pund EE, et al. N Engl J Med. 1960;263:835-838.
Curtiss EI, et al. Circulation. 1983;67(3):699-701.
Rohani A, et al. J Clin Imaging Sci. 2012;2:68.
Frustaci A, et al. Ann Intern Med. 2019. [Epub ahead of print].

URATE IN THE KIDNEYS? NO KIDDING!

Nickeleit V, Mihatsch MJ. Nephrol Dial Transplant. 1997;12(9):1832-1838.
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Gonick HC, et al. Ann Intern Med. 1965;62:667-674.
Bardin T, et al. Ann Rheum Dis. 2018;77(suppl 2):224.
Kim MY, et al. J of Korean Radiol Soc. 1994;31(3):523-527.
Hussein A, et al. Egypt J of Radiol Nuclear Med. 2015;46(4):1205-1213.
Jepperson MA, et al. Clin Radiol. 2013;68(12):e707-e714.
Fan S, et al. BMC Nephrology. 2019;20(1):95.
Brown J, Mallory GK. N Engl J Med. 1950;243:325-329.
Bluestone R, Waisman J, Klinenberg JR. Sem Arthritis Rheu. 1977;7:97-113.
Gonick HC, Rubini ME, Gleason IO, Sommers SC. Ann Intern Med. 1965; 62:667-674.
Wang XC, et al. Exp Ther Med. 2013;6(5):1243-1246.
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Johnson RJ, et al. Semin Nephrol. 2011;31(5):394-399.
Liebman SE, et al. Curr Rheumatol Rep. 2007;9(3)251-257.
Wiederkehr MR, Moe OW, et al. Clin Rev Bone Miner Metab. 2011;9(34)207-217.

SPINE-TINGLING IMAGES—URATE DEPOSITION IN THE BACK

Hasegawa E, et al. Rev Bras Reumatol. 2013;53(3):296-302.
Yang KH, ed. Basic Finite Element Method as Applied to Injury Biomechanics. Academic Press; 2018:609-654.
Toprover M, et al. Curr Rheumatol Rep. 2015;17(12):70.
Girish G, et al. Arthritis. 2013;2013:673401.
Chotard E, et al. Ann Rheum Dis. 2017;76:367-368.
Zhang H, et al. Int J Clin Exp Med. 2017;10(3):5493-5496.
Dhaese S, et al. Medicine (Baltimore). 2015;94(13):e676.
Parikh P, et al. J Rheumatol. 2010;37(10):2190-2191.
Lichtenstein L, et al. Am J Pathol. 1956;32(5):871-895.
Lu H, et al. Medicine. 2017;96(32):e7670.
Zhou S, et al. BMC Musculoskelet Disord. 2019;20(1):425.
Wang JX, et al. BMC Rheumatol. 2020;4:22.
Adler S, et al. Rheumatology. 2017;56(12):2243-2245.

OPEN YOUR EYES! LOOKING AT URATE DEPOSITION

Ao J, et al. Clin Exp Ophthalmol. 2017;45(1):73-80.
Odinaeva K, et al. Archiv Euromedica. 2020;10(1):111-112.
Odinaeva K, et al. Archiv Euromedica. 2020;10(1):109-110.
Jordan DR, et al. Ophthalmol Plast Reconstr Surg. 2008;24(5):403-404.
Morris WR, et al. Arch Ophthalmol. 2003;121(8):1195-1197.
Lo WR, et al. Am J Ophthalmol. 2005;140(6):1152-1154.
Lin J, et al. Int J Ophthalmol. 2013;6(3):307-311.
Coassin M, et al. Ophthalmology. 2006;113(3):462-465.
Jiang Y, et al. BMC Ophthalmol. 2018;18(1):11.
Singh JA, et al. PLoS One. 2018;13(7):e0199562.
McCarty CA, et al. Am J Ophthalmol. 1999;128(4):446-465.

URATE GETS UNDER YOUR SKIN

Pattanaprichakul P, et al. Dermatol Pract Concept. 2014;4(4):33-35.
Parlindungan F, et al. Am J Case Rep. 2020;21:e919349.
Kim M, et al. Korean J Intern Med. 2020;35(3):736-737.
Gianfaldoni S, et al. Open Access Maced J Med Sci. 2017;5(4):511-514.
Çerman AA, et al. An Bras Dermatol. 2016;91(6):855-856.