Professor Georg Schett, MD
Erlangen, Germany

Professor George Schett, MD Professor George Schett, MD Professor George Schett, MD

Professor Nicola Dalbeth, MD
Auckland, New Zealand

Professor Nicola Dalbeth, MD Professor Nicola Dalbeth, MD Professor Nicola Dalbeth, MD

"Both the monosodium urate crystals and the host inflammatory response contribute directly to bone erosion."

– PROFESSOR NICOLA DALBETH, MD

THE CYCLE OF DESTRUCTIVE INFLAMMATION IN GOUT1-4

Chart Cycle Image Chart Cycle Image Chart Cycle Image

Inflammation is initiated1

MSU crystals trigger acute inflammation1

Inflammation promotes destructive cellular behavior2,3

Osteoclast-like cells accumulate at the bone-tophus interface3
Cartilage cells signal to break down key components of cartilage2-4

Cellular death leads to increased local levels of uric acid1-3

DNA from dead cells breaks down into uric acid3

Uric acid triggers further inflammation1

Apart from acute flares and acute gout attacks, there is also a kind of smoldering inflammation, which is associated with swelling and pain, which is typical for tophaceous gout patients.

– PROFESSOR GEORG SCHETT, MD

GET MORE INFORMATION ABOUT THE CURRENT STATE OF GOUT RESEARCH

Additional resources

AMERICAN COLLEGE OF RHEUMATOLOGY (ACR) GUIDELINES FOR MANAGEMENT OF GOUTAMERICAN COLLEGE OF RHEUMATOLOGY (ACR) GUIDELINES FOR MANAGEMENT OF GOUT

AMERICAN COLLEGE OF RHEUMATOLOGY (ACR) GUIDELINES FOR MANAGEMENT OF GOUT

Is your sUA goal low enough to effectively reduce the signs and symptoms of gout and resolve tophi? Review the 2012 ACR guidelines to see if your gout treatment goals line up with industry recommendations.

CELLULAR CHARACTERIZATION OF THE GOUTY TOPHUS: A QUANTITATIVE ANALYSIS

CELLULAR CHARACTERIZATION OF THE GOUTY TOPHUS: A QUANTITATIVE ANALYSIS

Professor Nicola Dalbeth, MD’s 2010 article in Arthritis & Rheumatology details her team’s study of the cellular architecture of tophi, and how the cells present in the corona and fibrovascular zones of a tophus may contribute to a cycle of chronic inflammation.

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TAKE A DEEPER LOOK AT GOUT

View a comprehensive collection of curated medical images to see the range of damage that gout can cause.

See the damage
Uric AcidUric AcidUric Acid

WHAT YOU CAN DO

Learn about a treatment option for chronic gout.

Find out more

  • Schett G, et al. RMD Open. 2015 Aug 15;1(suppl 1):e000046.
  • Dalbeth N, et al. Arthritis Rheum. 2010;62(5):1549-1556.
  • McQueen FM, et al. Nat Rev Rheumatol. 2012;8(3):173-181.
  • Liu-Bryan R, et al. J Immunol. 2005;174(8):5016-5023.